Therapeutic spectrum of interferon‐β in ischemic stroke
نویسندگان
چکیده
منابع مشابه
After introduction of advanced therapeutic medicinal products (ATMPs) in Ischemic Stroke; novel therapeutic modalities from financial perspective
Stroke, is accounting for more than 34% of total healthcare spending globally. Ischemic stroke (IS) accounts for 62.4% of incident stroke cases. IS-related direct medical expenditures place a considerable burden on healthcare system. The burden is more prominent in developing countries where limitations in insurance coverage is a big concern. It would be less challenging in developed countries,...
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近年,脳梗塞の治療では心筋梗塞の治療と同様に早 期診断・早期治療の重要性が叫ばれ,心筋梗塞が “Heart Attack”と呼ばれ可急的速やかに治療され一命 をとりとめるように,脳梗塞も“Brain Attack”と捉え 同様に速やかに治療を行い,後遺症を最小限にくいと めることの重要性が認識されつつある.脳虚血が発症 して脳血流が遮断されると脳組織は数時間で不可逆性 の変化をきたし壊死に陥って梗塞となる.ひとたび脳 梗塞に罹患すると片麻痺や言語障害などの神経症候, 記憶・記銘力の低下や情緒障害などの精神症状,さら にQOLの低下や痴呆症などの後遺症に苦しむことに なり社会的生命を失うことにもなる. 近年CT(computed tomography),MRI・A(magnetic resonance imaging・angiography),SPECT(single photon e...
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Intravenous recombinant tissue plasminogen activator remains the only US FDA-approved treatment for acute ischemic stroke. However, the very limited time window for its administration restricts its usefulness. Furthermore, it is becoming increasingly clear that, given the numerous pathways via which cerebral ischemia causes cell death, the capacity to inhibit multiple mechanisms simultaneously ...
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Ischemic stroke has been classified as a merely thrombotic disease, so the main goal of its treatment is the recanalization of the occluded vasculature. However, despite fast restoration of blood circulation, progressive stroke still develops in many patients, which has led to the concept of reperfusion injury. The underlying mechanism is only partly known. Though, it is accepted now, tha...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2018
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.24333